Dr Jenny Wang
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About
Overview
Jenny's research sits at the intersection of computational modelling, cardiac physiology and clinical medicine. She develops biophysically detailed models of cardiac electrophysiology and mechanics, spanning from ion channel behaviour in single cells to the electromechanical function of the whole heart, and uses finite element simulation to link changes at the molecular level to measurements taken in the clinic. A central strand of her work is the cardiac digital twin: a personalised model built from an individual's imaging and ECG data using statistical inference methods such as sequential Monte Carlo approximate Bayesian computation, which can then be used to make mechanistic predictions about that individual's cardiac health.
Her particular focus is on female-specific life events, especially pregnancy and the postpartum period. Pregnancy places substantial demands on the maternal heart, and hypertensive disorders such as pre-eclampsia are associated with lasting cardiovascular risk that remains poorly understood. Jenny's longer-term aim is to develop digital twins that can follow cardiac health across the life course and help predict which treatments or lifestyle changes will benefit a given patient at preconception, during pregnancy and after birth. This work is carried out in close collaboration with clinicians and researchers based at the John Radcliffe Hospital in Oxford and King's College London.
Jenny completed her PhD at the Auckland Bioengineering Institute in 2018 and then spent over eight years at the University of Oxford in the Computational Cardiovascular Science group, first with Professor Alfonso Bueno-Orovio and subsequently with Professor Blanca Rodriguez. Her research there progressed from electrophysiological modelling of hypertrophic cardiomyopathy, through electromechanical modelling of the infarcted heart, to the development and validation of cardiac digital twin pipelines. She joined City St George's in September 2026 and retains a visitor affiliation at Oxford.
Qualifications
- PhD in Biomedical Engineering, University of Auckland, New Zealand, January 2014 - September 2018
- Bachelors in Biomedical Engineering, University of Auckland, New Zealand, February 2010 - December 2013
Employment
- Lecturer in Biomedical Engineering, City St Georges', University of London, United Kingdom, September 2026 - present
- Senior Postdoctoral Research Associate, University of Oxford, United Kingdom, October 2019 - September 2026
- Junior Postdoctoral Research Associate, University of Oxford, United Kingdom, April 2018 - September 2019
Languages
Chinese (Mandarin) (can read, write, speak, understand spoken)
Publications
Publications by category
Chapters (2)
- Camps, J., Wang, Z.J., Doste, R., Berg, L.A., Holmes, M., Lawson, B.... Rodriguez, B. (2024). Open Source Cardiac Digital Twinning of Human Ventricular Repolarisation from 12-Lead ECG and MRI. Frontiers in Artificial Intelligence and Applications IOS Press.
- Wang, Z.J., Wang, V.Y., Huang, S.-.M., Niestrawska, J.A., Young, A.A. and Nash, M.P. (2015). Identifying Myocardial Mechanical Properties from MRI Using an Orthotropic Constitutive Model. Lecture Notes in Computer Science (pp. 135-144). Springer International Publishing. ISBN 9783319146775.
Journal articles (12)
- Tomek, J., Holmes, M., Martinez-Navarro, H., Zhou, X., Hasaballa, A.I., Wang, Z.J.... Heijman, J. (2026). T-World Virtual Human Cardiomyocyte. II. Organ-Scale Simulations and Applications. Circulation Research, 138(10). doi:10.1161/circresaha.125.328123
- Camps, J., Wang, Z.J., Doste, R., Berg, L.A., Holmes, M., Lawson, B.... Rodriguez, B. (2025). Harnessing 12-lead ECG and MRI data to personalise repolarisation profiles in cardiac digital twin models for enhanced virtual drug testing. Medical Image Analysis, 100, pp. 103361-103361. doi:10.1016/j.media.2024.103361
- Zhou, X., Wang, Z.J., Camps, J., Tomek, J., Santiago, A., Quintanas, A.... Rodriguez, B. (2024). Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations. eLife, 13. doi:10.7554/elife.93002.3
- Riebel, L.L., Wang, Z.J., Martinez-Navarro, H., Trovato, C., Camps, J., Berg, L.A.... Rodriguez, B. (2024). In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity, heterogeneity and Purkinje in human. Scientific Reports, 14(1). doi:10.1038/s41598-024-67951-5
- Li, L., Camps, J., Jenny Wang, Z., Beetz, M., Banerjee, A., Rodriguez, B.... Grau, V. (2024). Toward Enabling Cardiac Digital Twins of Myocardial Infarction Using Deep Computational Models for Inverse Inference. IEEE Transactions on Medical Imaging, 43(7), pp. 2466-2478. doi:10.1109/tmi.2024.3367409
- Camps, J., Berg, L.A., Wang, Z.J., Sebastian, R., Riebel, L.L., Doste, R.... Rodriguez, B. (2024). Digital twinning of the human ventricular activation sequence to Clinical 12-lead ECGs and magnetic resonance imaging using realistic Purkinje networks for in silico clinical trials. Medical Image Analysis, 94, pp. 103108-103108. doi:10.1016/j.media.2024.103108
- Wang, Z.J., Santiago, A., Zhou, X., Wang, L., Margara, F., Levrero-Florencio, F.... Rodriguez, B. (2021). Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction. EP Europace, 23(Supplement_1), pp. i143-i152. doi:10.1093/europace/euaa405
- Margara, F., Wang, Z.J., Levrero-Florencio, F., Santiago, A., Vázquez, M., Bueno-Orovio, A.... Rodriguez, B. (2021). In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment. Progress in Biophysics and Molecular Biology, 159, pp. 58-74. doi:10.1016/j.pbiomolbio.2020.06.007
- Levrero-Florencio, F., Margara, F., Zacur, E., Bueno-Orovio, A., Wang, Z.J., Santiago, A.... Rodriguez, B. (2020). Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant biomarkers. Computer Methods in Applied Mechanics and Engineering, 361, pp. 112762-112762. doi:10.1016/j.cma.2019.112762
- Wang, Z.J., Wang, V.Y., Babarenda Gamage, T.P., Rajagopal, V., Cao, J.J., Nielsen, P.M.F.... Nash, M.P. (2020). Efficient estimation of load‐free left ventricular geometry and passive myocardial properties using principal component analysis. International Journal for Numerical Methods in Biomedical Engineering, 36(3). doi:10.1002/cnm.3313
- Coppini, R., Ferrantini, C., Pioner, J.M., Santini, L., Wang, Z.J., Palandri, C.... Sherrid, M.V. (2019). Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy. JACC: Basic to Translational Science, 4(7), pp. 795-813. doi:10.1016/j.jacbts.2019.06.004
- Wang, Z.J., Wang, V.Y., Bradley, C.P., Nash, M.P., Young, A.A. and Cao, J.J. (2018). Left Ventricular Diastolic Myocardial Stiffness and End-Diastolic Myofibre Stress in Human Heart Failure Using Personalised Biomechanical Analysis. Journal of Cardiovascular Translational Research, 11(4), pp. 346-356. doi:10.1007/s12265-018-9816-y
Other
- Wang, J.(2022). Multi-scale human-based cardiac modelling and simulation in hypertrophic cardiomyopathy and post-myocardial infarction.